Circulating cell-free DNA fragmentation is a stepwise and conserved process linked to apoptosis
Abstract Background Circulating cell-free DNA (cfDNA) is a pool of short DNA fragments mainly released from apoptotic hematopoietic cells.Nevertheless, the precise physiological process Scullcap governing the DNA fragmentation and molecular profile of cfDNA remains obscure.To dissect the DNA fragmentation process, we use a human leukemia cell line